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The activation of GLP-1R promotes the release of -endorphins, which mediate analgesic effects through receptors at the neuronal level [39, 42]

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Ozempic, Wegovy, Rybelsus, Mounjaro, Saxenda, and other medications in this drug class were originally developed for type 2 diabetes treatment and blood sugar management, but their widespread use for weight loss dramatically expanded the number of patients exposed to these medications